Programmable Biomaterials Laboratory

Can we use structural material properties on the nanoscale to engineer selective interactions at the bio-interface?

The goal of the Programmable Biomaterials Lab is to understand the molecular design rules behind selective multivalent interactions at the bio-interface. We use DNA as engineering tool to explore the importance of structural mechanics and precise control of valency and patterns on directional interactions and self-assembly.


Combining materials engineering with biophysics and molecular biology, we uniquely combine disciplines to unravel and translate the power of selective interactions in the low-valency regime.


Exploiting the multitude of structural properties presented by DNA, we create macromolecules that organize into functional materials to unravel the selective multivalent interplay with cellular interactions.


Read the latest work from Diana on how mechanical properties on the nanoscale mediate DNA-membrane binding. 

  • DNA nanotechnology
  • Supramolecular polymer self-assembly
  • Soft matter
  • Cell uptake and stability
  • Immune engineering
Those who are inspired by a model other than Nature, a mistress above all masters, are laboring in vain.
Leonardo da Vinci
Latest publications

Check out the publication by Eva and Marianna here