DNA origami as immunomodulators

The programmability of DNA as a biomaterial is exploited in the “DNA origami” technique for engineering self-assembling nanostructures with an unprecedented level of uniformity in size and spacing of ligand presentation. The control of ligand positioning with nanoscale precision is a potent tool to investigate ligand receptor interactions. In particular, DNA origami nanoparticles mimicking viruses in size and shape are designed to study dendritic cell activation and the immune response. Understanding the best spacing of ligands for the activation of the dendritic cells constitutes an essential feature for the development of vaccines with enhanced potency and specificity.

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