DNA crosslinked hydrogels

Filippo project photo.001

The mechanical properties of both natural and synthetic extracellular matrices (ECM) greatly influence cell phenotype and function. Tunable control over synthetic ECM material properties is therefore essential for successful cell culture, as differentiation depends on the cellular environment and the biophysical signals that the latter transmits. Responsive hydrogels have great potential as substrates for cell culture, since chemical, physical and biological cues can be used to determine the cells’ phenotype and function. Our aim is to use DNA as programmable cross-link to control the self-assembly and properties of hydrogels.

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